CD22
CD22，又被稱為Siglec-2，普遍存在于正常B細(xì)胞和B細(xì)胞惡性腫瘤中。CD22主要表達(dá)于成熟B細(xì)胞，是具有調(diào)控B細(xì)胞激活作用的細(xì)胞表面粘附分子，有助于B細(xì)胞對(duì)抗原反應(yīng)敏感性的控制。此外，有研究進(jìn)一步證明了CD22表達(dá)在B細(xì)胞中具有特異性，并且在小鼠和人類中都受到發(fā)育調(diào)控。CD22作為B細(xì)胞受體（BCR）的一個(gè)共受體，通過抗原引起CD22與BCR交聯(lián)，觸發(fā)CD22磷酸化，使下游信號(hào)蛋白去磷酸化和失活，從而抑制BCR信號(hào)傳導(dǎo)，防止自身免疫性疾病的發(fā)生。意味著，CD22表達(dá)或功能受損在自身免疫性疾病的發(fā)病機(jī)制中起重要作用，如系統(tǒng)性紅斑狼瘡(SLE)、類風(fēng)濕性關(guān)節(jié)炎(RA)等。因此，作為限制B細(xì)胞的抗原，CD22為治療自身免疫疾病和血液癌癥中的B細(xì)胞失調(diào)提供了有效靶點(diǎn)。
Recombinant Human CD22 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CD22 Antibodies
CD22 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004900ESR1HU | CD22 Antibody | Human | ELISA, IHC |
| CSB-PA828492 | CD22 Antibody | Human | ELISA,WB |
| CSB-PA912726 | Phospho-CD22 (Tyr807) Antibody | Human | ELISA,WB |
| CSB-PA953915 | CD22 (Ab-807) Antibody | Human | ELISA,WB |
| CSB-PA070293 | Phospho-CD22 (Y807) Antibody | Human | WB, IHC, ELISA |
| CSB-PA070294 | CD22 Antibody | Human | WB, ELISA |
| CSB-PA616669 | CD22 Antibody | Human | ELISA,IHC |
| CSB-PA576542 | CD22 Antibody | Human | ELISA,IHC |
| CSB-RA962691A0HU | CD22 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CD22 Proteins
CD22 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004900HU CSB-BP004900HU CSB-EP004900HU-B |
Recombinant Human B-cell receptor CD22 (CD22), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP004900HU1 | Recombinant Human B-cell receptor CD22 (CD22), partial | E.coli |
| CSB-MP004900HU | Recombinant Human B-cell receptor CD22 (CD22), partial (Active) | Mammalian cell |
| CSB-MP004900HU-B | Recombinant Human B-cell receptor CD22 (CD22), partial,Biotinylated | Mammalian cell |
CD22 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004900MO CSB-EP004900MO CSB-BP004900MO CSB-MP004900MO CSB-EP004900MO-B |
Recombinant Mouse B-cell receptor CD22 (Cd22), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP865045GGZ CSB-EP865045GGZ CSB-BP865045GGZ CSB-MP865045GGZ CSB-EP865045GGZ-B |
Recombinant Gorilla gorilla gorilla B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP868228EXP CSB-EP868228EXP CSB-BP868228EXP CSB-MP868228EXP CSB-EP868228EXP-B |
Recombinant Pongo pygmaeus B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882013EQV CSB-EP882013EQV CSB-BP882013EQV CSB-MP882013EQV CSB-EP882013EQV-B |
Recombinant Pan troglodytes B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD22 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP885632EQU CSB-EP885632EQU CSB-BP885632EQU CSB-MP885632EQU CSB-EP885632EQU-B |
Recombinant Pan paniscus B-cell receptor CD22 (CD22) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
