免疫檢查點

免疫檢查點是免疫激活的調控因子，主要在免疫應答過程中調節(jié)T細胞受體（TCR）的抗原識別。它們在維持免疫穩(wěn)態(tài)和預防自身免疫方面至關重要。根據不同的免疫激活作用，免疫檢查點可分為兩種類型：共刺激免疫檢查點和共抑制免疫檢查點。共刺激免疫檢查點是指一系列可以進一步刺激免疫反應的免疫檢查點，如CD28，ICOS和CD137。相反，共抑制免疫檢查點對抑制免疫反應的免疫檢查點，如PD1，CTLA-4和VISTA。在有效的抗腫瘤免疫過程中，T細胞作為核心的執(zhí)行者，首先被T細胞受體介導的抗原識別信號激活，同時眾多的共刺激信號和共抑制信號精細調節(jié)T細胞反應的強度和質量。在生理情況下，共刺激分子與免疫檢查點分子保持平衡，從而最大程度減少對于周圍正常組織的損傷，維持對自身組織的耐受、避免自身免疫反應。而腫瘤細胞可以通過此機制，異常上調共抑制分子及其相關配體，抑制T細胞激活，從而逃避免疫殺傷。

PD-L1(CD274) or PD-L2(CD273) CD80 or CD86 ICOSL(CD275) CD276 / VICN1 VISTA HHLA2 Butyrophilin Family Members (e.g. Btnl2 , Skint1, MOG , CD277 ) HVEM(CD270) MHC class I or II TNFSF9(CD137L) OX40L(CD252) TNFSF7(CD70) TNFRSF5(CD40) GIRL(TNFSF18) PVR(CD155) NECTIN-2(CD112) MOX1(CD200) BCM-1(CD48) Gal-9 Adenosine IDO1 ; TDO ? PD-1(CD279) CD28(TP44) CTLA-4(CD152) ICOS(CD278) ? ? TMIGD2(CD28H) ? ? BTLA(CD272) KIR_S KIR_L TCR LAG-3(CD223) TNFRSF-9(CD137) OX40(CD134) TNFRSF7(CD27) CD40L(CD154) GITR(CD357) CD96 DNAM-1(CD226) TIGIT CD112R CD200R 2B4(CD244) TIM-3(CD366) A2aR Tryptophan

免疫檢查點產品

近幾年， CUSABIO研發(fā)團隊致力于靶向免疫研究，為廣大科研用戶開發(fā)了一系列免疫檢查點重組蛋白。這些重組免疫檢查點蛋白涵蓋多種物種和標簽，秉承客戶至上的原則，所有蛋白產品在發(fā)貨前我們都會對其生物活性進行再次分析和驗證。另外，我們還提供蛋白質定制服務，如果您找不到您需要的蛋白質，請聯(lián)系我們進行定制服務。

產品名稱	貨號	規(guī)格
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005131HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005141HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005151HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005171HU	1mg(1mg1 or 500ug2)/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human CD160 antigen (CD160) (Active)	CSB-AP005221HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	CSB-AP005241HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	CSB-AP005251HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active)	CSB-AP005261HU	1mg(1mg1 or 500ug2)/500μg/50μg/10μg
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active)	CSB-AP005271HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	100ug/20ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Mouse Tumor necrosis factor receptor superfamily member 14 (Tnfrsf14), partial (Active)	CSB-AP005311MO	1mg(1mg1 or 500ug2)/500ug/50ug/10ug