Human calcitonin gene related peptide,CGRP ELISA Kit

Human calcitonin gene related peptide,CGRP ELISA Kit

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文獻引用 (30) 說明書下載

中文名稱：

人降鈣素基因相關肽(CGRP)酶聯免疫試劑盒
貨號：

CSB-E08210h
規格：

96T/48T
價格：

￥3600/￥2500
其他：

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產品描述：

人降鈣素基因相關肽(CGRP)酶聯免疫試劑盒（CSB-E08210h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的CGRP含量。CGRP（降鈣素基因相關肽）是一種神經肽。在它在偏頭痛等疾病發病機制中扮演重要角色。研究機制上，它能擴張腦血管、調節神經炎癥。針對 CGRP 及其受體開發藥物以阻斷其作用，成為偏頭痛等治療的新策略。試劑盒檢測范圍為1.56 pg/mL-100 pg/mL，適用于體外研究CGRP在神經生物學、心血管功能、疼痛機制或炎癥模型中的動態變化，例如評估實驗動物模型中CGRP的釋放水平、細胞因子刺激下培養細胞的分泌特征，或藥物干預對組織內CGRP表達的影響等科研用途本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Beta type CGRP ELISA Kit; Beta-CGRP ELISA Kit; Beta-type CGRP ELISA Kit; CALC2 ELISA Kit; Calcb ELISA Kit; CALCB_HUMAN ELISA Kit; Calcitonin gene related peptide 2 ELISA Kit; Calcitonin gene related peptide II ELISA Kit; Calcitonin gene-related peptide 2 ELISA Kit; Calcitonin gene-related peptide II ELISA Kit; Calcitonin related polypeptide; beta ELISA Kit; CGRP II ELISA Kit; CGRP-II ELISA Kit; CGRP2 ELISA Kit; CGRPII ELISA Kit; FLJ30166 ELISA Kit
縮寫：

CGRP
Uniprot No.：

P10092
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, cell culture supernates, tissue homogenates
檢測范圍：

1.56 pg/mL-100 pg/mL
靈敏度：

0.39 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human CGRP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	85
	Range %	80-92
1:2	Average %	96
	Range %	91-105
1:4	Average %	97
	Range %	92-110
1:8	Average %	90
	Range %	86-98

回收率：

The recovery of human CGRP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	94	89-98
EDTA plasma (n=4)	96	90-100

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
100	2.660	2.511	2.586	2.432
50	2.080	2.152	2.116	1.962
25	1.451	1.366	1.409	1.255
12.5	0.795	0.744	0.770	0.616
6.25	0.491	0.523	0.507	0.353
3.12	0.315	0.325	0.320	0.166
1.56	0.248	0.244	0.246	0.092
0	0.157	0.151	0.154

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia ?K Can, U Cabus, C Kabukcu, S Fenkci,Clinical and Experimental Obstetrics & Gynecology,2025
Influence of Constipation in the Behavior of Circulating Alpha-and Beta-CGRP Levels in Chronic/High-Frequency Migraine Patients After CGRP Monoclonal Antibodies G Gárate, M Polanco, J Madera, M Mu?oz-San Martín,Biomedicines,2025
The Role of TRPV1/CGRP Pathway Activated by Prevotella melaninogenica in Pathogenesis of Oral Lichen Planus P Xu, R Shao, P Zhu, J Fei, Y He,International Journal of Molecular Sciences,2025
Low serum 25‐hydroxyvitamin D levels in migraine are not related to headache frequency: A case‐control study in patients with high‐frequency/chronic migraine M Haro, G Gárate, JL Hernández,Headache,2025
ILC2-derived CGRP triggers acute inflammation and nociceptive responses in bacterial cystitis Z Yang, Y Liu, Y Xiang, R Chen, L Chen, S Wang, L Lv,Cell Reports,2024
Untangling the mess of CGRP levels as a migraine biomarker: an in-depth literature review and analysis of our experimental experience G Garate Vi?as, J Pascual Gómez, M Pascual Mato,UNIVERSIDAD DE CANTABRIA,2024
Unravelling the role of beta-CGRP in inflammatory bowel disease and its potential role in gastrointestinal homeostasis M Pascual-Mato, G Gárate, V González-Quintanilla,BMC Gastroenterology,2024
Dynamic fluctuations of salivary CGRP levels during migraine attacks: association with clinical variables and phenotypic characterization L Asskour,The journal of headache and pain,2024
Geschlechtsspezifische Aspekte der Migr?ne B Raffaelli,Dissertationen Charité-Universit?tsmedizin Berlin,/
Untangling the mess of CGRP levels as a migraine biomarker: an in-depth literature review and analysis of our experimental experience G Gárate,The journal of headache and pain,2024
Calcitonin gene_x001e_related peptide alleviates hyperoxia_x001e_induced human alveolar cell injury via the CGRPR/TRPV1/Ca2+ axis JH Li,Molecular medicine reports,/
One‐droplet saliva detection on photonic crystal‐based competitive immunoassay for precise diagnosis of migraine X Lin,/,2023
Salivary CGRP and erenumab treatment response: towards precision medicine in migraine A Alpuente,Annals of Neurology,2023
Bone Geometry, Density, Microstructure, and Biomechanical Properties in the Distal Tibia in Patients With Primary Hypertrophic Osteoarthropathy Assessed by Second-Generation High-Resolution Peripheral Quantitative Computed Tomography Q Pang,Journal of bone and mineral research,2023
Visible-light-responsive reduced graphene oxide/g-C3N4/TiO2 composite nanocoating for photoelectric stimulation of neuronal and osteoblastic differentiation Z Yan,RSC advances,2023
P177 Beta-CGRP in inflammatory bowel disease: a protective neuropeptide of the gut EY Ali,/,2024
Migraine molecular phenotyping through the study of the calcitonin gene-related peptide: towards precision medicine A Alpuente Ruiz - 2023 - tdx.cat,/,2023
Reader Response: Sex hormones and calcitonin gene-related peptide in women with migraine: a cross-sectional, matched cohort study J Pascual,Neurology,2023
P087 Calcitonin gene related peptide beta (CGRPβ): a new player in inflammatory bowel disease pathophysiology M Pascual,Journal of Crohn's and Colitis,2023
P114 Increased serum levels of the migraine biomarker calcitonin gene related peptide alpha in a newly diagnosed inflammatory bowel disease population: a new?… M Pascual,Journal of Crohn's and Colitis,2023
Serum Calcitonin Gene-Related Peptide α and β Levels are Increased in COVID-19 Inpatients G Gárate,Archives of medical research,2023
Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism Y Cheng,Drug design, development and therapy,2022
Increase in Serum Calcitonin Gene-Related Peptide β (CGRPβ) Levels in COVID-19 Patients with Diarrhea: An Underlying Mechanism? G Gárate,Digestive diseases and sciences,2022
Baseline tear fluid CGRP is elevated in active cluster headache patients as long as they have not taken attack abortive medication K Kamm,Cephalalgia,2020
Changes in ET-1, Plasma Neuropeptide Y, and CGRP in Child Patients With Congenital Heart Disease Complicated With Pulmonary Hypertension Before and After Operation Z Liu,Clinical ediatrics,2020
Correlation between CGRP Levels and the Neuropathic and Inflammatory Component of Postoperative Pain D Neychev,Folia Med (Plovdiv),2020
Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls Katharina Kamm,Cephalalgia,2019
3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair Wu J, et al,Journal of Biomaterials Applications,2018
Fasting serum CGRP levels are related to calcium concentrations, but cannot be elevated by short-term calcium/vitamin D supplementation. Hu F.et al,Neuropeptides.,2015
Plasma level of calcitonin gene-related peptide in patients with polycystic ovary syndrome and its relationship to hormonal and metabolic parameters Zhe Zhang et al,Peptides,2012

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功能：

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
基因功能參考文獻：
1. The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element. PMID: 26967115
2. Keratinocyte-derived CGRPbeta may modulate epidermal homeostasis through autocrine/paracrine signaling and may contribute to chronic pain under pathological conditions. PMID: 21641113
3. Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells. PMID: 19192276
亞細胞定位：

Secreted.
蛋白家族：

Calcitonin family
數據庫鏈接：

HGNC: 1438

OMIM: 114160

KEGG: hsa:797

STRING: 9606.ENSP00000346017

UniGene: Hs.534305

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.